Fatty acid synthase inhibitors from Geum japonicum Thunb. var. chinense.
نویسندگان
چکیده
Bioassay-guided fractionation of the MeOH extract of Geum japonicum Thunb. var. chinense using the fatty acid synthase inhibition assay led to the isolation of a new dimeric ellagitannin, gemin G (1), together with six known compounds, gemin A (2), casuarinin (3), pedunculagin (4), potentillin (5) , tellimagrandin II (6), and ellagic acid (7). Their structures were determined on the basis of spectroscopic analyses. Compounds 1-7 displayed strong inhibitory activities on fatty acid synthase with IC(50) values in the range of 0.21-41.4 microM. Compounds 1-4 exhibited significant antioxidant activities higher than vitamin C in the ORAC assay. Compounds 1 and 2 also showed weak cytotoxic effects on BGC-823 cell.
منابع مشابه
Allelopathy of the invasive plant Bidens frondosa on the seed germination of Geum japonicum var. chinense.
Five gradient concentrations (0.02, 0.04, 0.06, 0.08, and 0.10 g/mL) of leaching liquors from the roots, stems, and leaves of the invasive plant Bidens frondosa were used as conditioning fluid to examine its influence on seed germination conditions of the native plant Geum japonicum var. chinense in Huangshan. All leaching liquors of organs suppressed the seed germination of Geum japonicum var....
متن کاملHost plants of Empria sawflies (Hymenoptera, Tenthredinidae) in Japan include Rhododendron (Ericaceae).
New host plant records are given for six Empria species from Japan. They are Rosa multiflora [Rosaceae] for E. honshuana Prous & Heidemaa, 2011, Rubus sp. [Rosaceae] for E. japonica Heidemaa & Prous, 2011, Geum japonicum and G. calthifolium var. nipponicum [Rosaceae] for E. loktini Ermolenko, 1971, Rosa multiflora, Potentilla indica and probably Rubus parvifolius [Rosaceae] for E. quadrimaculat...
متن کاملA new phloroglucinol diglycoside derivative from Hypericum japonicum Thunb.
A new phloroglucinol diglycoside 1, together with eight known compounds, were isolated from Hypericum japonicum Thunb. The structure of the new compound 1 was determined by spectroscopic methods to be 4,6-dimethyl-5-O-[alpha-L-rhamnopyranosyl-(1-->6)-alpha-D-glucopyranosyl] multifidol. Different solvent extracts of Hypericum japonicum Thunb. were tested for in vivo antihypoxic activity using mi...
متن کاملA new anti-HIV triterpene from Geum japonicum.
Geumonoid (1), a new triterpene, was isolated from Geum japonicum. Its structure was elucidated on the basis of 1D, 2D NMR and MS spectroscopic analysis. Compound 1 showed inhibitory activity against HIV-1 protease.
متن کاملCapsaicin Synthesis Requires in Situ Phenylalanine and Valine Formation in in Vitro Maintained Placentas from Capsicum chinense.
Capsaicinoids (CAP) are nitrogenous metabolites formed from valine (Val) and phenylalanine (Phe) in the placentas of hot Capsicum genotypes. Placentas of Habanero peppers can incorporate inorganic nitrogen into amino acids and have the ability to secure the availability of the required amino acids for CAP biosynthesis. In order to determine the participation of the placental tissue as a supplie...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemistry & biodiversity
دوره 6 3 شماره
صفحات -
تاریخ انتشار 2009